Description

5-[(3,5-Difluorophenyl)Hydroxymethyl]-2-Fluorobenzonitrile is a high-purity fluorinated benzonitrile derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique molecular scaffold, which is designed to introduce specific fluorinated aromatic and hydroxymethyl functionalities into target molecules, enabling the development of compounds with enhanced biological activity and metabolic stability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel active ingredients in drug discovery and crop protection programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting the central nervous system, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorinated phenyl group can improve lipophilicity and target binding.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials that require fluorinated aromatic units for specific electronic or physical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-[(3,5-Difluorophenyl)Hydroxymethyl]-2-Fluorobenzonitrile
CAS No.	1108745-07-8
Molecular Formula	C14H8F3NO
Molecular Weight	263.22 g/mol
Synonyms	2-Fluoro-5-[(3,5-difluorophenyl)(hydroxy)methyl]benzonitrile; 5-[(3,5-Difluorophenyl)(hydroxy)methyl]-2-fluorobenzonitrile; 2-Fluoro-5-[(3,5-difluorophenyl)hydroxymethyl]benzonitrile; 1108745-07-8; Benzonitrile, 2-fluoro-5-[(3,5-difluorophenyl)hydroxymethyl]-; 5-[(3,5-Difluorobenzyl)alcohol]-2-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 5-[(3,5-Difluorophenyl)Hydroxymethyl]-2-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.