Description

1-Bromo-2-Chloro-5-Nitro-3-(Trifluoromethyl)Benzene is a high-purity, multi-functional halogenated aromatic building block of significant commercial importance. Its unique structure, featuring bromo, chloro, nitro, and trifluoromethyl substituents, makes it a versatile intermediate for synthesizing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients. Its reliable quality and consistent supply are critical for accelerating product development timelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing complex, high-performance dyes and pigments with specific color fastness and stability properties.
• Cross-Coupling Reactions: The bromo and chloro groups make it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro group activates the aromatic ring for substitution reactions, allowing for further functionalization.

Basic Information

Product Name	1-Bromo-2-Chloro-5-Nitro-3-(Trifluoromethyl)Benzene
CAS No.	1096698-02-0
Molecular Formula	C7H2BrClF3NO2
Molecular Weight	304.45 g/mol
Synonyms	2-Bromo-1-Chloro-4-Nitro-5-(Trifluoromethyl)Benzene; 3-Trifluoromethyl-1-Bromo-2-Chloro-5-Nitrobenzene; 5-Nitro-3-(Trifluoromethyl)-1-Bromo-2-Chlorobenzene; 1-Bromo-2-Chloro-5-Nitro-α,α,α-Trifluorotoluene; Benzene, 1-bromo-2-chloro-5-nitro-3-(trifluoromethyl)-; 2-Chloro-5-nitro-3-(trifluoromethyl)bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Chloro-5-Nitro-3-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.