Description

Benzonitrile, 4-Amino-3-Fluoro-2-(Trifluoromethyl)- is a high-value, multi-functional aromatic intermediate featuring a unique trifluoromethyl and amino substitution pattern. This compound is critical for the synthesis of advanced pharmaceutical agents and agrochemicals, where its structure imparts desirable properties like metabolic stability and enhanced bioavailability. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms for improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic nitrile core and fluorine substituents.
• Chemical Biology & Proteomics: Employed as a versatile scaffold or labeling agent in the development of biochemical probes and enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring complex fluorinated benzonitrile derivatives.

Basic Information

Product Name	Benzonitrile, 4-Amino-3-Fluoro-2-(Trifluoromethyl)-
CAS No.	1095188-12-7
Molecular Formula	C8H4F4N2
Molecular Weight	204.13 g/mol
Synonyms	4-Amino-3-fluoro-2-(trifluoromethyl)benzonitrile; 2-(Trifluoromethyl)-4-amino-3-fluorobenzonitrile; 3-Fluoro-4-amino-2-trifluoromethylbenzonitrile; 4-Amino-3-fluoro-α,α,α-trifluoro-o-tolunitrile; 2-Cyano-5-fluoro-6-(trifluoromethyl)aniline; 2-Trifluoromethyl-4-amino-3-fluorobenzonitrile; 4-Amino-α,α,α,3-tetrafluoro-o-tolunitrile
EINECS	Contact for details

Quality Control

Our production of Benzonitrile, 4-Amino-3-Fluoro-2-(Trifluoromethyl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by HPLC, GC, NMR, and mass spectrometry. We operate in compliance with cGMP guidelines where applicable, ensuring the material meets the exacting standards required for pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.