Description

5-Ethynyl-2-Fluorobenzonitrile is a high-value, multi-functional aromatic nitrile building block featuring both a reactive ethynyl group and a fluorine substituent. This compound is essential for advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides with enhanced efficacy and selectivity.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced organic electronic materials.
• Chemical Synthesis: Employed in Sonogashira, Click Chemistry (azide-alkyne cycloaddition), and other palladium-catalyzed cross-coupling reactions to introduce fluorinated aromatic systems.
• Ligand & Catalyst Development: Utilized to create novel ligands for catalysis and molecular recognition applications.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the effects of fluorine substitution on reactivity and physical properties in organic molecules.

Basic Information

Product Name	5-Ethynyl-2-Fluorobenzonitrile
CAS No.	1093306-86-5
Molecular Formula	C9H4FN
Molecular Weight	145.14 g/mol
Synonyms	2-Fluoro-5-ethynylbenzonitrile; 5-Ethynyl-2-fluorobenzonitrile; 2-Fluoro-5-(ethynyl)benzonitrile; Benzonitrile, 5-ethynyl-2-fluoro-; (5-Cyano-2-fluorophenyl)acetylene
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-2-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber glass or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.