Description

3-Ethoxy-2,6-Difluorophenylacetonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both ethoxy and difluoro substituents, makes it a versatile precursor for constructing complex heterocycles and active pharmaceutical ingredients (APIs). This compound is primarily targeted at research and development (R&D) chemists and process development scientists within the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorine-containing motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Serves as a crucial building block for creating advanced herbicides, fungicides, and insecticides where the difluorophenyl moiety enhances metabolic stability and bioavailability.
• Liquid Crystal & OLED Material Precursor: Used in the synthesis of fluorinated aromatic cores for electronic and optoelectronic applications, contributing to improved material performance.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, cyano-group transformations, and as a scaffold for constructing complex polyfunctional aromatic compounds in academic and industrial research.

Basic Information

Product Name	3-Ethoxy-2,6-Difluorophenylacetonitrile
CAS No.	1092461-33-0
Molecular Formula	C10H9F2NO
Molecular Weight	197.18 g/mol
Synonyms	2-(3-Ethoxy-2,6-difluorophenyl)acetonitrile; (3-Ethoxy-2,6-difluorophenyl)acetonitrile; 3-Ethoxy-2,6-difluorobenzeneacetonitrile; α-Cyano-3-ethoxy-2,6-difluorotoluene; 1092461-33-0; Acetonitrile, (3-ethoxy-2,6-difluorophenyl)-
EINECS	Contact for details

Quality Control

Our 3-Ethoxy-2,6-Difluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.