Description

5-Chloro-2-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional aromatic nitrile building block distinguished by its chloro and trifluoromethoxy substituents. This compound is essential for advanced organic synthesis, offering a unique combination of electronic and steric properties that facilitate the development of novel chemical entities. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes due to its aromatic core and halogenated motifs.
• Polymer & Resin Modifiers: Incorporated to develop high-performance polymers with specific thermal, chemical, or surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex molecular architectures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethoxy)Benzonitrile
CAS No.	1092461-25-0
Molecular Formula	C8H3ClF3NO
Molecular Weight	221.56 g/mol
Synonyms	2-Chloro-5-(trifluoromethoxy)benzonitrile; 5-Chloro-α,α,α-trifluoro-o-anisonitrile; 2-Cyano-4-chloro-1-(trifluoromethoxy)benzene; 4-Chloro-2-(trifluoromethoxy)benzonitrile; Benzonitrile, 5-chloro-2-(trifluoromethoxy)-; 1-Chloro-4-cyano-2-(trifluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethoxy)Benzonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under GMP or ISO-guided frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.