Description

5-Chloro-2-(trifluoromethoxy)phenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique trifluoromethoxy and chloro substituents impart desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals for advanced electronic and optical applications.
• Custom Synthesis and Contract Manufacturing: A starting material for custom chemical synthesis services catering to specific client R&D projects.

Basic Information

Product Name	5-Chloro-2-(trifluoromethoxy)phenylacetonitrile
CAS No.	1092461-20-5
Molecular Formula	C9H5ClF3NO
Molecular Weight	235.59 g/mol
Synonyms	2-(5-Chloro-2-(trifluoromethoxy)phenyl)acetonitrile; (5-Chloro-2-(trifluoromethoxy)phenyl)acetonitrile; 5-Chloro-α-(trifluoromethoxy)phenylacetonitrile; 2-(5-Chloro-2-(trifluoromethoxyl)phenyl)acetonitrile; 1092461-20-5; 5-Chloro-2-trifluoromethoxyphenylacetonitrile; α-(5-Chloro-2-(trifluoromethoxy)phenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(trifluoromethoxy)phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.