Description

2,6-Dichloro-3-(Trifluoromethyl)Phenylacetonitrile is a high-value, multi-functional chemical intermediate characterized by its unique halogenated and nitrile-bearing aromatic structure. This compound matters for its critical role in facilitating complex molecular transformations, particularly in the synthesis of advanced active ingredients. It is primarily needed by research and development teams and production chemists in the pharmaceutical and agrochemical industries for constructing novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl and chloro groups contribute to bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its rigid, halogenated aromatic core.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures for drug discovery.
• Nitrile Transformation: The nitrile functional group can be converted into amides, acids, or tetrazoles, expanding its utility in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	2,6-Dichloro-3-(Trifluoromethyl)Phenylacetonitrile
CAS No.	1092461-09-0
Molecular Formula	C9H4Cl2F3N
Molecular Weight	254.04 g/mol
Synonyms	2,6-Dichloro-α-(trifluoromethyl)benzeneacetonitrile; (2,6-Dichloro-3-(trifluoromethyl)phenyl)acetonitrile; 2,6-Dichloro-3-trifluoromethylphenylacetonitrile; Benzeneacetonitrile, 2,6-dichloro-α-(trifluoromethyl)-; 2,6-Dichloro-3-(trifluoromethyl)benzyl cyanide; 1092461-09-0; 2,6-Dichloro-α-(trifluoromethyl)phenylacetonitrile
EINECS	Contact for details

Quality Control

Every batch of 2,6-Dichloro-3-(Trifluoromethyl)Phenylacetonitrile is produced and tested under a strict quality management system. We guarantee high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.