Description

5-Fluoro-2-(trifluoromethoxy)phenylacetonitrile is a high-value fluorinated aromatic nitrile building block, essential for introducing specific steric and electronic properties into advanced molecular architectures. Its unique structure, combining fluorine and trifluoromethoxy substituents, makes it a critical intermediate for synthesizing compounds with enhanced metabolic stability, lipophilicity, and binding affinity. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Functional Material Research: Employed in organic synthesis for creating novel polymers, ligands for catalysis, and specialty chemicals with tailored properties.
• Chemical Biology Probes: Utilized as a building block for developing fluorescent tags and molecular probes used in diagnostic and biochemical research.

Basic Information

Product Name	5-Fluoro-2-(trifluoromethoxy)phenylacetonitrile
CAS No.	1092460-90-6
Molecular Formula	C9H5F4NO
Molecular Weight	219.14 g/mol
Synonyms	2-(5-Fluoro-2-(trifluoromethoxy)phenyl)acetonitrile; (5-Fluoro-2-(trifluoromethoxy)phenyl)acetonitrile; 5-Fluoro-2-(trifluoromethoxy)benzyl cyanide; α-Cyano-5-fluoro-2-(trifluoromethoxy)toluene; 1092460-90-6; 5-Fluoro-2-trifluoromethoxyphenylacetonitrile; 2-(5-Fluoro-2-(trifluoromethoxy)phenyl)ethanenitrile
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(trifluoromethoxy)phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment supports applications requiring high-purity intermediates for GLP and cGMP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.