Description

5-Fluoro-2-(trifluoromethoxy)benzonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced chemical synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, makes it a critical intermediate for developing compounds with enhanced biological activity and physicochemical properties. This compound is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the fluorine and trifluoromethoxy groups contribute to improved efficacy and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs) due to its ability to modify dielectric anisotropy and viscosity.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Advanced Material Research: A versatile reagent in academic and industrial R&D for creating complex fluorinated molecules with tailored properties for specialty polymers and coatings.
• Chemical Synthesis Reagent: Acts as a pivotal intermediate in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution to introduce the benzonitrile core into more complex molecular architectures.

Basic Information

Product Name	5-Fluoro-2-(Trifluoromethoxy)Benzonitrile
CAS No.	1092460-82-6
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	2-Cyano-4-fluoro-1-(trifluoromethoxy)benzene; 4-Fluoro-2-(trifluoromethoxy)benzonitrile; 5-Fluoro-2-(trifluoromethoxy)phenyl cyanide; 1-Cyano-5-fluoro-2-(trifluoromethoxy)benzene; 2-Trifluoromethoxy-5-fluorobenzonitrile; Benzonitrile, 5-fluoro-2-(trifluoromethoxy)-; 5-Fluoro-α,α,α-trifluoro-o-tolunitrile 2-oxide (related structure)
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(trifluoromethoxy)benzonitrile is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality system supports compliance with cGMP and ISO standards for reliable sourcing in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.