Description

1-Chloro-2-Fluoro-4-Methoxy-5-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogen and nitro groups for bioactivity.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Intermediate: Employed in the synthesis of complex azo dyes and other high-performance colorants.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination to create biaryl structures.
• Chemical Research & Development: A versatile building block for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	1-Chloro-2-Fluoro-4-Methoxy-5-Nitrobenzene
CAS No.	1089280-66-9
Molecular Formula	C7H5ClFNO3
Molecular Weight	205.57 g/mol
Synonyms	2-Chloro-1-Fluoro-4-Methoxy-5-Nitrobenzene; 4-Chloro-3-Fluoro-6-Nitroanisole; 5-Nitro-2-Chloro-1-Fluoro-4-Methoxybenzene; Benzene, 1-chloro-2-fluoro-4-methoxy-5-nitro-; 1-Chloro-2-fluoro-4-methoxy-5-nitro-benzene; 2-Fluoro-4-methoxy-5-nitrochlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-Fluoro-4-Methoxy-5-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, minimize exposure to direct light during handling and storage.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.