Description

1-(3,5-Bis(Trifluoromethyl)Phenyl)-1H-Imidazole is a high-value, fluorinated heterocyclic building block designed for advanced chemical synthesis. This compound matters for its unique structural features, combining a phenyl-imidazole core with electron-withdrawing trifluoromethyl groups, which impart significant lipophilicity and metabolic stability. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing novel active ingredients, particularly in medicinal chemistry for kinase inhibitors and in crop protection.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of small molecule drugs, especially as a core scaffold for kinase inhibitors targeting various disease pathways.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Catalyst Ligand: The imidazole nitrogen can act as a coordinating site in transition metal catalysis for various organic transformations.
• Chemical Research: Employed in academic and industrial R&D for exploring structure-activity relationships (SAR) and developing new fluorinated compounds.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Item	Details
Product Name	1-(3,5-Bis(Trifluoromethyl)Phenyl)-1H-Imidazole
CAS No.	1088567-34-3
Molecular Formula	C12H6F6N2
Molecular Weight	292.19 g/mol
Synonyms	1-[3,5-Bis(trifluoromethyl)phenyl]-1H-imidazole; 1H-Imidazole, 1-[3,5-bis(trifluoromethyl)phenyl]-; 3,5-Bis(trifluoromethyl)phenyl imidazole; α,α,α,α',α',α'-Hexafluoro-3,5-xylyl imidazole; 1-(3,5-Di(trifluoromethyl)phenyl)imidazole
EINECS	Contact for details

Quality Control

Our 1-(3,5-Bis(Trifluoromethyl)Phenyl)-1H-Imidazole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and production standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.