Description

Benzonitrile, 4-(2-Hydroxycyclohexyl)-2-(Trifluoromethyl)- is a specialized organic intermediate featuring a benzonitrile core substituted with a trifluoromethyl group and a hydroxycyclohexyl moiety. This unique molecular architecture makes it a valuable building block for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), particularly where the introduction of fluorine atoms and specific stereochemistry is required. It is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, where the trifluoromethyl group can enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the biological activity imparted by the fluorine substituents.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its potential influence on electronic properties and molecular alignment.
• Advanced Polymer Chemistry: Incorporated into specialty polymers to modify thermal stability, chemical resistance, and surface properties.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.
• Fluorine Chemistry Studies: Acts as a model compound for studying the effects of fluorinated aromatic systems on reaction kinetics and molecular interactions.

Basic Information

Product Name	Benzonitrile, 4-(2-Hydroxycyclohexyl)-2-(Trifluoromethyl)-
CAS No.	1076225-26-7
Molecular Formula	C14H14F3NO
Molecular Weight	269.26 g/mol
Synonyms	4-(2-Hydroxycyclohexyl)-2-(trifluoromethyl)benzonitrile; 2-(Trifluoromethyl)-4-(2-hydroxycyclohexyl)benzonitrile; 4-(2-Hydroxycyclohexyl)-α,α,α-trifluoro-o-tolunitrile; [1076225-26-7]; (2-Hydroxycyclohexyl)(4-cyano-3-(trifluoromethyl)phenyl)methane (tautomeric form)
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-(2-Hydroxycyclohexyl)-2-(Trifluoromethyl)- is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP requirements for pharmaceutical development and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider the use of desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.