Description

2(R)-2-Trifluoromethylpyrrolidine CAS NO 1073556-31-6 is a high-value, chiral pyrrolidine derivative distinguished by the presence of a trifluoromethyl group at the stereogenic 2-position. This unique structural motif makes it a critical advanced pharmaceutical intermediate and a versatile chiral building block for modern synthetic chemistry. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for CNS-targeting therapeutics and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with unique fluorinated properties.
• Medicinal Chemistry & SAR Studies: Essential for structure-activity relationship studies to optimize the potency and pharmacokinetic profiles of lead compounds.
• Process Chemistry & Scale-up: Used in the development and optimization of commercial-scale synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2(R)-2-Trifluoromethylpyrrolidine
CAS No.	1073556-31-6
Molecular Formula	C5H8F3N
Molecular Weight	139.12 g/mol
Synonyms	(R)-2-(Trifluoromethyl)pyrrolidine; (R)-2-Trifluoromethylpyrrolidine; (2R)-2-(Trifluoromethyl)pyrrolidine; (R)-α-(Trifluoromethyl)pyrrolidine; Pyrrolidine, 2-(trifluoromethyl)-, (2R)-; 2-Trifluoromethylpyrrolidine, (R)-; (R)-2-Trifluoromethyl-1-pyrrolidine; (R)-1-Pyrrolidine, 2-trifluoromethyl-
EINECS	Contact for details

Quality Control

Our 2(R)-2-Trifluoromethylpyrrolidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids and strong bases. Due to its fluoride/strong alkali chemical property, ensure proper segregation in storage areas.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.