Description

2-(2-Fluoro-4-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides.
• Material Science: Precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Research: Enables academic and industrial R&D for new chemical entities via palladium-catalyzed cross-coupling.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic complexes.
• Fluorinated Compound Libraries: Critical for medicinal chemistry programs focused on incorporating fluorine to modulate pharmacokinetic properties.

Basic Information

Item	Detail
Product Name	2-(2-Fluoro-4-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1073353-89-5
Molecular Formula	C12H15BFNO4
Molecular Weight	279.07 g/mol
Synonyms	2-Fluoro-4-nitrophenylboronic acid pinacol ester; (2-Fluoro-4-nitrophenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2-fluoro-4-nitrophenyl)-1,3,2-dioxaborolane; 2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2-fluoro-4-nitrophenyl)boronate; (2-Fluoro-4-nitrophenyl)pinacolboronate; 1073353-89-5
EINECS	Contact for details

Quality Control

Our 2-(2-Fluoro-4-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.