Description

Loratadine CAS NO 1073332-71-4 is a potent, long-acting tricyclic antihistamine that selectively antagonizes peripheral H1 receptors. This compound is critical for providing effective, non-sedating relief from allergic symptoms. It is an essential active pharmaceutical ingredient (API) for manufacturers in the global pharmaceutical industry, primarily used in the formulation of allergy and hay fever medications.

Application

• Primary Active Pharmaceutical Ingredient (API) in non-sedating antihistamine tablets and syrups.
• Key component in over-the-counter (OTC) allergy relief medications for seasonal allergic rhinitis.
• Used in prescription formulations for chronic idiopathic urticaria (hives).
• Raw material for combination drug products targeting multiple allergy symptoms.
• Starting material for pharmaceutical research and development of new antihistamine derivatives.
• Reference standard in quality control laboratories for analytical method development and validation.

Basic Information

Product Name	Loratadine
CAS No.	1073332-71-4
Molecular Formula	C22H23ClN2O2
Molecular Weight	382.88 g/mol
Synonyms	Ethyl 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate; SCH-29851; Fristamin; Clarityn; Claritin; Lisino; Alavert; Lortadin; Lorfast; Alaver
EINECS	Contact for details

Quality Control

Our Loratadine is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identification, assay, and control of specified impurities. Certificates of Analysis (COA) confirming compliance with in-house specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.