Description

Pregna-1,4-Diene-3,20-Dione, 11,17-Dihydroxy-6-Methyl-, (6β,11β)- is a high-purity steroid derivative, also known as 6β-Methylprednisolone, valued for its potent glucocorticoid activity and role as a key pharmaceutical intermediate. This compound is essential for research and development in the synthesis of advanced corticosteroid-based therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing anti-inflammatory and immunosuppressive drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients) like Methylprednisolone and its derivatives.
• Anti-inflammatory Drug Research: Serves as a reference standard and starting material in R&D for novel anti-inflammatory and immunosuppressive agents.
• Metabolite Studies: Used in analytical and bioanalytical laboratories for metabolism and pharmacokinetic studies of related steroid drugs.
• Process Development: Employed in chemical process optimization and scale-up for the commercial manufacturing of steroid pharmaceuticals.
• Quality Control Standard: Acts as a high-purity analytical standard for HPLC, LC-MS, and other chromatographic methods in pharmaceutical QC labs.

Basic Information

Item	Detail
Product Name	Pregna-1,4-Diene-3,20-Dione, 11,17-Dihydroxy-6-Methyl-, (6β,11β)-
CAS No.	1048031-80-6
Molecular Formula	C22H30O5
Molecular Weight	374.47 g/mol
Synonyms	6β-Methylprednisolone; 6β-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; (6β,11β)-11,17-Dihydroxy-6-methylpregna-1,4-diene-3,20-dione; 6-Methyl-δ1-hydrocortisone; 6β-Methyl-δ1-cortisol; 6β-Methylprednisolone (unspecified isomer); 6-Methylprednisolone (6β-isomer)
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 11,17-Dihydroxy-6-Methyl-, (6β,11β)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under inert atmosphere is recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.