Description

4-(3-Fluoro-2-Methylphenyl)-4,5-Dihydrooxazol-2-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique oxazoline scaffold with a fluorinated aromatic substituent. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and inflammatory pathways. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to incorporate fluorinated heterocycles into new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeting and anti-inflammatory drugs.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to explore fluorinated chemical space.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Ligand Synthesis: Potential precursor for chiral oxazoline ligands used in asymmetric catalysis.
• Agrochemical Research: Investigated as an intermediate for developing new fluorinated agrochemicals with enhanced biological activity and stability.
• Chemical Biology Probes: Useful for creating molecular probes to study enzyme function and biological pathways due to its fluorinated aromatic group.

Basic Information

Product Name	4-(3-Fluoro-2-Methylphenyl)-4,5-Dihydrooxazol-2-Amine
CAS No.	1043498-53-8
Molecular Formula	C10H11FN2O
Molecular Weight	194.21 g/mol
Synonyms	2-Amino-4-(3-fluoro-2-methylphenyl)-4,5-dihydrooxazole; 4,5-Dihydro-4-(3-fluoro-2-methylphenyl)-2-oxazolamine; 4-(3-Fluoro-2-methylphenyl)-2-amino-4,5-dihydrooxazole; 2-Oxazolamine, 4,5-dihydro-4-(3-fluoro-2-methylphenyl)-; 4-(3-Fluoro-o-tolyl)-4,5-dihydrooxazol-2-amine; 4-(3-Fluoro-2-methylphenyl)-2-amino-2-oxazoline; FMOA Intermediate; 1043498-53-8
EINECS	Contact for details

Quality Control

Our 4-(3-Fluoro-2-Methylphenyl)-4,5-Dihydrooxazol-2-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.