Description

2-(3,4-Difluorophenyl)-2-Methylpropanenitrile is a versatile fluorinated nitrile building block, a key intermediate in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms and a reactive nitrile group, enabling the construction of complex molecules with tailored properties. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in CNS and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the difluorophenyl moiety enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a key starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Functional Material Development: Employed in polymer and material science to create specialty polymers, coatings, and additives with specific performance characteristics.
• Cross-Coupling Reactions: The aromatic ring is amenable to various palladium-catalyzed cross-coupling reactions (Suzuki, Heck) for creating complex biaryl structures.
• Nitrile Transformation Chemistry: The nitrile group can be converted into amides, carboxylic acids, amines, or tetrazoles, expanding its utility in medicinal chemistry.

Basic Information

Item	Details
Product Name	2-(3,4-Difluorophenyl)-2-Methylpropanenitrile
CAS No.	1035262-16-8
Molecular Formula	C10H9F2N
Molecular Weight	181.18 g/mol
Synonyms	2-(3,4-Difluorophenyl)-2-methylpropionitrile; α,α-Dimethyl-3,4-difluorobenzeneacetonitrile; 2-Methyl-2-(3,4-difluorophenyl)propanenitrile; 3,4-Difluoro-α,α-dimethylbenzeneacetonitrile; (3,4-Difluorophenyl)(isopropyl)acetonitrile; Isopropyl(3,4-difluorophenyl)acetonitrile; 1035262-16-8
EINECS	Contact for details

Quality Control

Our 2-(3,4-Difluorophenyl)-2-Methylpropanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Purity (HPLC/GC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.