Description

1-(3-Trifluoromethylbenzyl)-1H-Pyrazole-4-Carboxylic Acid Ethyl Ester is a high-value fluorinated pyrazole derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group is prized for its ability to modulate biological activity and metabolic stability. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the pyrazole and trifluoromethyl motifs.
• Chemical Biology Probe Synthesis: Employed in constructing molecular probes for studying enzyme function and biological pathways.
• Material Science Precursor: Serves as a starting material for synthesizing specialty polymers or liquid crystals with unique electronic or optical properties.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and scale-up services for client projects.

Basic Information

Product Name	1-(3-Trifluoromethylbenzyl)-1H-Pyrazole-4-Carboxylic Acid Ethyl Ester
CAS No.	1035224-53-3
Molecular Formula	C14H13F3N2O2
Molecular Weight	298.26 g/mol
Synonyms	Ethyl 1-[(3-(trifluoromethyl)phenyl)methyl]-1H-pyrazole-4-carboxylate; 1-[(3-Trifluoromethyl)benzyl]-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 1-(3-Trifluoromethylbenzyl)-1H-pyrazole-4-carboxylate ethyl ester; Ethyl 1-((3-(trifluoromethyl)benzyl)-1H-pyrazole-4-carboxylate; 1-(3-(Trifluoromethyl)benzyl)-1H-pyrazole-4-carboxylic acid ethyl ester; 1035224-53-3; 1H-Pyrazole-4-carboxylic acid, 1-[(3-(trifluoromethyl)phenyl)methyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of 1-(3-Trifluoromethylbenzyl)-1H-Pyrazole-4-Carboxylic Acid Ethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.