Description

3-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Benzonitrile is a high-value fluorinated aromatic nitrile building block, essential for introducing specific steric and electronic properties into advanced molecular architectures. Its core value lies in its unique trifluoromethyl and fluoro substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target compounds. This intermediate is primarily needed by R&D and process development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging the fluorine motifs for enhanced bioactivity.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals where fluorine incorporation improves chemical resistance and optical properties.
• Organic Electronics: Investigated as a component in the synthesis of electron-transport materials for OLEDs and other electronic devices.
• Chemical Biology Probes: Utilized in creating tagged molecules and probes for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development of scalable synthetic routes.

Basic Information

Product Name	3-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Benzonitrile
CAS No.	1032506-84-5
Molecular Formula	C14H7F4N
Molecular Weight	265.21 g/mol
Synonyms	3-[4-Fluoro-3-(trifluoromethyl)phenyl]benzonitrile; [1,1'-Biphenyl]-3-carbonitrile, 4'-fluoro-3'-(trifluoromethyl)-; 4'-Fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-3-carbonitrile; 3-(4-Fluoro-3-trifluoromethylphenyl)benzonitrile; 3-(4-Fluoro-3-(trifluoromethyl)phenyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 3-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with ISO standards and meets the stringent requirements for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.