Description

2-Iodo-4-Fluorobenzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring iodine, fluorine, and a nitrile group, makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and functionalized ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in the development of kinase inhibitors, CNS-active compounds, and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine and iodine substituents can enhance biological activity and environmental stability.
• Material Science: Serves as a building block for organic electronic materials, including liquid crystals (LCs) and organic light-emitting diodes (OLEDs), due to its polarizable halogen atoms and rigid aromatic core.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to create complex biaryl and conjugated systems.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and as a standard reagent for functional group transformation studies.
• Ligand and Catalyst Design: The nitrile and halogen groups allow for further functionalization to create specialized ligands for metal-organic frameworks (MOFs) and homogeneous catalysis.

Basic Information

Product Name	2-Iodo-4-Fluorobenzonitrile
CAS No.	1031929-20-0
Molecular Formula	C7H3FIN
Molecular Weight	262.01 g/mol
Synonyms	4-Fluoro-2-iodobenzonitrile; 2-Iodo-4-fluorobenzonitrile; Benzonitrile, 2-iodo-4-fluoro-; 2-Iodo-4-fluorophenyl cyanide; 4-Fluoro-2-iodobenzene carbonitrile; 1031929-20-0; 2-I-4-F-BN
EINECS	Contact for details

Quality Control

Our 2-Iodo-4-Fluorobenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP standards where applicable, ensuring the material is suitable for demanding research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.