Description

2-Amino-3,5-Dichloro-6-Fluorobenzonitrile is a high-purity, multi-halogenated benzonitrile derivative serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique molecular scaffold, which combines amino, cyano, and halogen functionalities, enabling precise chemical modifications for creating complex target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms contribute to enhanced biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its rigid, halogenated aromatic structure.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating molecular probes, enzyme inhibitors, and labeled compounds for biochemical research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in fluorinated and chlorinated heterocyclic chemistry.

Basic Information

Product Name	2-Amino-3,5-Dichloro-6-Fluorobenzonitrile
CAS No.	1027514-29-9
Molecular Formula	C7H3Cl2FN2
Molecular Weight	205.02 g/mol
Synonyms	6-Fluoro-2-amino-3,5-dichlorobenzonitrile; 3,5-Dichloro-6-fluoro-2-aminobenzonitrile; 2-Amino-3,5-dichloro-6-fluorobenzene-1-carbonitrile; Benzonitrile, 2-amino-3,5-dichloro-6-fluoro-; 1027514-29-9; 2-Amino-3,5-dichloro-6-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 2-Amino-3,5-Dichloro-6-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistent batch-to-batch reproducibility for your development and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.