Description

(6α,11β)-6,9-Difluoro-11-Hydroxypregna-1,4,16-Triene-3,20-Dione CAS NO 1027011-66-0 is a high-purity synthetic steroid derivative characterized by its unique fluorinated pregnane structure. This compound is of significant value as a critical pharmaceutical intermediate in the development of novel anti-inflammatory and corticosteroid-based therapeutics. It is primarily required by research institutions and pharmaceutical manufacturers engaged in advanced drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potent glucocorticoid receptor agonists.
• Drug Discovery & Development: Used in medicinal chemistry research for creating new chemical entities targeting inflammatory pathways.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial production of steroid-based APIs.
• Biochemical Research: Applied in studies investigating steroid hormone action and receptor binding affinity.

Basic Information

Product Name	(6α,11β)-6,9-Difluoro-11-Hydroxypregna-1,4,16-Triene-3,20-Dione
CAS No.	1027011-66-0
Molecular Formula	C21H24F2O4
Molecular Weight	378.41 g/mol
Synonyms	6α,9α-Difluoro-11β,17α,21-Trihydroxy-16-methylenepregna-1,4-diene-3,20-dione; 6α,9α-Difluoroprednisolone 16-methylene; 6α,9α-Difluoro-16-methyleneprednisolone; 16-Methylene-6α,9α-difluoroprednisolone; (6α,11β,17α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione; Difluoromethyleneprednisolone
EINECS	Contact for details

Quality Control

Our (6α,11β)-6,9-Difluoro-11-Hydroxypregna-1,4,16-Triene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity suitable for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.