Description

3-Fluoro-5-(Hydroxymethyl)Benzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a reactive nitrile group and a hydroxymethyl substituent on a fluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The benzonitrile moiety can act as a directing group or be further functionalized in palladium-catalyzed cross-coupling reactions.
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer backbones to alter thermal stability, solubility, and other material properties.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating novel chemical entities in academic and industrial R&D labs.

Basic Information

Product Name	3-Fluoro-5-(Hydroxymethyl)Benzonitrile
CAS No.	1021871-34-0
Molecular Formula	C8H6FNO
Molecular Weight	151.14 g/mol
Synonyms	5-(Hydroxymethyl)-3-fluorobenzonitrile; 3-Fluoro-5-(hydroxymethyl)benzonitrile; 3-Fluoro-5-hydroxymethylbenzonitrile; Benzonitrile, 3-fluoro-5-(hydroxymethyl)-; (3-Cyano-5-fluorophenyl)methanol; 3-Fluoro-5-cyanobenzyl alcohol
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-5-(Hydroxymethyl)Benzonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.