Description

4-Fluoro-3-(trifluoromethoxy)phenylacetonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced chemical synthesis. This compound matters for its unique molecular architecture, combining fluorine and trifluoromethoxy substituents to impart significant electronic and steric properties to target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for CNS and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions like Suzuki and Buchwald-Hartwig couplings for complex molecule assembly.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethoxy)phenylacetonitrile
CAS No.	1020718-23-3
Molecular Formula	C9H5F4NO
Molecular Weight	219.14 g/mol
Synonyms	2-[4-Fluoro-3-(trifluoromethoxy)phenyl]acetonitrile; (4-Fluoro-3-(trifluoromethoxy)phenyl)acetonitrile; 4-Fluoro-α-(trifluoromethoxy)benzeneacetonitrile; 2-(4-Fluoro-3-(trifluoromethoxyphenyl)acetonitrile; 4-Fluoro-3-trifluoromethoxyphenylacetonitrile; F-TFMPA; 1020718-23-3
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(trifluoromethoxy)phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO-aligned processes guarantees a reliable supply of high-purity material for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.