Description

2-Ethoxy-3,5-Difluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both ethoxy and difluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and device efficiency.
• Advanced Polymer Chemistry: Incorporated as a monomer or cross-linking agent to create specialty polymers with enhanced thermal stability, chemical resistance, and unique optical properties.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in exploring new reaction pathways, catalysis, and material science applications.
• Fluorine Chemistry Library Synthesis: Essential for constructing diverse compound libraries in medicinal chemistry for high-throughput screening and structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-Ethoxy-3,5-Difluorophenylacetonitrile
CAS No.	1017779-84-8
Molecular Formula	C10H9F2NO
Molecular Weight	197.18 g/mol
Synonyms	2-(2-Ethoxy-3,5-difluorophenyl)acetonitrile; 3,5-Difluoro-2-ethoxyphenylacetonitrile; (2-Ethoxy-3,5-difluorophenyl)acetonitrile; 2-Ethoxy-3,5-difluorobenzeneacetonitrile; Acetonitrile, (2-ethoxy-3,5-difluorophenyl)-; 1017779-84-8; α-Cyano-2-ethoxy-3,5-difluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 2-Ethoxy-3,5-Difluorophenylacetonitrile undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and traceability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong alkalis and fluorides. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.