Description

4-Ethoxy-2,6-Difluorophenylacetonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring both ethoxy and difluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed in the development of novel organic semiconductors and charge-transport materials.
• Chemical Research: A versatile building block for academic and industrial research in medicinal chemistry and material science.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule construction.

Basic Information

Product Name	4-Ethoxy-2,6-Difluorophenylacetonitrile
CAS No.	1017779-53-1
Molecular Formula	C10H9F2NO
Molecular Weight	197.18 g/mol
Synonyms	2-(4-Ethoxy-2,6-difluorophenyl)acetonitrile; 4-Ethoxy-2,6-difluorobenzyl cyanide; (4-Ethoxy-2,6-difluorophenyl)acetonitrile; 1017779-53-1; Acetonitrile, 2-(4-ethoxy-2,6-difluorophenyl)-; 2,6-Difluoro-4-ethoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Production of 4-Ethoxy-2,6-Difluorophenylacetonitrile is monitored through in-process controls and validated analytical methods, including HPLC, GC, and NMR, to ensure batch-to-batch consistency and high purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality system supports compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.