Description

4-(Difluoromethoxy)-2-Fluoro-Benzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique difluoromethoxy and fluoro substituents impart desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development teams in pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), where fluorine substitution improves performance.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and lowering surface energy.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex heterocyclic systems in academic and industrial labs.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a precursor for synthesizing fluorine-18 labeled radiotracers for medical imaging.

Basic Information

Product Name	4-(Difluoromethoxy)-2-Fluoro-Benzonitrile
CAS No.	1017779-49-5
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	2-Fluoro-4-(difluoromethoxy)benzonitrile; 4-(Difluoromethoxy)-2-fluorobenzonitrile; 2-Fluoro-α,α-difluoro-p-cyanophenol methyl ether; Benzonitrile, 4-(difluoromethoxy)-2-fluoro-; 1017779-49-5
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-2-Fluoro-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.