Description

4-Ethoxy-3,5-Difluorophenylacetonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring ethoxy and difluoro substitutions on the phenyl ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection agent discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the difluorophenyl moiety enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electron-transport materials.
• Cross-Coupling Reactions: The nitrile and halogenated aryl structure makes it a suitable substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new fluorinated heterocycles and complex molecular architectures.

Basic Information

Product Name	4-Ethoxy-3,5-Difluorophenylacetonitrile
CAS No.	1017779-41-7
Molecular Formula	C10H9F2NO
Molecular Weight	197.18 g/mol
Synonyms	2-(4-Ethoxy-3,5-difluorophenyl)acetonitrile; (4-Ethoxy-3,5-difluorophenyl)acetonitrile; 3,5-Difluoro-4-ethoxyphenylacetonitrile; 4-Ethoxy-3,5-difluorobenzeneacetonitrile; α-Cyano-4-ethoxy-3,5-difluorotoluene; 1017779-41-7; Acetonitrile, (4-ethoxy-3,5-difluorophenyl)-
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-3,5-Difluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.