Description

4-Ethoxy-3,5-Difluorobenzonitrile is a high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique substitution pattern enables precise molecular design. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the development of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the synthesis of electron-transport materials and semiconductors for OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating novel fluorinated compound libraries.

Basic Information

Product Name	4-Ethoxy-3,5-Difluorobenzonitrile
CAS No.	1017779-27-9
Molecular Formula	C9H7F2NO
Molecular Weight	183.16 g/mol
Synonyms	3,5-Difluoro-4-ethoxybenzonitrile; Benzonitrile, 3,5-difluoro-4-ethoxy-; 4-Ethoxy-3,5-difluorobenzonitrile; 3,5-Difluoro-4-ethoxybenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-3,5-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.