Description

2-Methoxy-4-(Trifluoromethyl)Phenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical industries, due to the unique properties imparted by the trifluoromethyl and methoxy substituents. It serves as a key intermediate for researchers and manufacturers developing active ingredients, advanced materials, and fine chemicals requiring specific electronic and steric characteristics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its aromatic and fluorinated structure.
• Fine Chemical & Dye Intermediate: Employed in the production of specialized dyes, pigments, and other high-value fine chemicals requiring specific substitution patterns.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems for material science and drug discovery.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in medicinal chemistry and organic synthesis for exploring new chemical spaces.

Basic Information

Product Name	2-Methoxy-4-(Trifluoromethyl)Phenylacetonitrile
CAS No.	1017779-20-2
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	2-Methoxy-α-(trifluoromethyl)benzeneacetonitrile; [2-Methoxy-4-(trifluoromethyl)phenyl]acetonitrile; 4-(Trifluoromethyl)-2-methoxyphenylacetonitrile; 2-Methoxy-4-trifluoromethylphenylacetonitrile; (2-Methoxy-4-(trifluoromethyl)phenyl)acetonitrile; α-Cyano-2-methoxy-4-(trifluoromethyl)toluene
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and batch-to-batch consistency suitable for sensitive synthesis applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.