Description

3-Chloro-4-Ethoxy-5-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring chloro, ethoxy, and fluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for the synthesis of fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Polymer Chemistry: Acts as a monomer or modifier in the production of specialty polymers, including high-performance resins and engineering plastics with enhanced chemical resistance.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new chemical reactions, catalytic processes, and as a standard in analytical method development.
• Dye & Pigment Intermediate: Utilized in the synthesis of advanced dyes and functional pigments, where the benzonitrile core and halogen substituents allow for color tuning and stability.

Basic Information

Product Name	3-Chloro-4-Ethoxy-5-Fluorobenzonitrile
CAS No.	1017778-99-2
Molecular Formula	C9H7ClFNO
Molecular Weight	199.61 g/mol
Synonyms	5-Fluoro-3-chloro-4-ethoxybenzonitrile; 4-Ethoxy-3-chloro-5-fluorobenzonitrile; 3-Chloro-4-ethoxy-5-fluorobenzene carbonitrile; Benzonitrile, 3-chloro-4-ethoxy-5-fluoro-; 1017778-99-2; 3-Chloro-4-ethoxy-5-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Ethoxy-5-Fluorobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.