Description

3-Chloro-4-Ethoxy-5-Fluorophenylacetonitrile is a high-value, multi-functional aromatic nitrile building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, due to its reactive cyano group and halogen/ether substituents. It is primarily sought after by R&D chemists and process development teams for creating active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel drug candidates, especially in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used as a precursor for herbicides and fungicides, leveraging the fluorine and chlorine atoms for bioactivity.
• Liquid Crystal Materials: Serves as a building block for advanced electronic display components due to its aromatic core and polarizable groups.
• Organic Synthesis & Research: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and cyano group transformations for academic and industrial R&D.
• Fine Chemical Production: Integral to the multi-step synthesis of dyes, pigments, and other specialty chemicals.

Basic Information

Product Name	3-Chloro-4-Ethoxy-5-Fluorophenylacetonitrile
CAS No.	1017778-94-7
Molecular Formula	C10H9ClFNO
Molecular Weight	213.64 g/mol
Synonyms	2-(3-Chloro-4-ethoxy-5-fluorophenyl)acetonitrile; (3-Chloro-4-ethoxy-5-fluorophenyl)acetonitrile; 3-Chloro-4-ethoxy-5-fluorobenzeneacetonitrile; 1017778-94-7; 3-Chloro-4-ethoxy-5-fluoro-benzeneacetonitrile; α-(3-Chloro-4-ethoxy-5-fluorophenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Ethoxy-5-Fluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.