Description

2-Methoxy-3-(trifluoromethyl)phenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a methoxy and a trifluoromethyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Acts as a building block for advanced electronic materials, where its aromatic core and fluorine atoms contribute to desired dielectric and emissive properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, cyano-group transformations, and as a scaffold for constructing complex heterocycles in medicinal chemistry.
• Chemical Research & Development: Essential for academic and industrial R&D labs exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	2-Methoxy-3-(trifluoromethyl)phenylacetonitrile
CAS No.	1017778-81-2
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	2-Methoxy-α-(trifluoromethyl)benzeneacetonitrile; (2-Methoxy-3-(trifluoromethyl)phenyl)acetonitrile; 2-Methoxy-3-trifluoromethylphenylacetonitrile; 2-Methoxy-3-(trifluoromethyl)benzyl cyanide; α-Cyano-2-methoxy-3-(trifluoromethyl)toluene; 1017778-81-2; 3-Trifluoromethyl-2-methoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 2-Methoxy-3-(trifluoromethyl)phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality parameters to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.