Description

2-Fluoro-4,6-Bis(Trifluoromethyl)Phenylacetonitrile is a high-value, multi-fluorinated aromatic nitrile building block. This compound matters for its unique trifluoromethyl and fluorine substituents, which impart exceptional lipophilicity, metabolic stability, and electronic properties to target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas, where fluorine substitution is critical for bioactivity and ADME properties.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethyl groups for enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores used in electronic display materials and organic semiconductors.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty fluoropolymers with high thermal stability, chemical resistance, and low surface energy.
• Chemical Research & Development: A versatile reagent for exploring new reactions in fluoroorganic chemistry and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	2-Fluoro-4,6-Bis(Trifluoromethyl)Phenylacetonitrile
CAS No.	1017778-50-5
Molecular Formula	C11H4F7N
Molecular Weight	283.15 g/mol
Synonyms	2-Fluoro-α,α-bis(trifluoromethyl)benzeneacetonitrile; (2-Fluoro-4,6-bis(trifluoromethyl)phenyl)acetonitrile; 2-Fluoro-4,6-bis(trifluoromethyl)benzyl cyanide; α-(2-Fluoro-4,6-bis(trifluoromethyl)phenyl)acetonitrile; 1017778-50-5; 2-Fluoro-4,6-di(trifluoromethyl)phenylacetonitrile
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4,6-Bis(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We support cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.