Description

2-(Difluoromethoxy)-5-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique difluoromethoxy and fluorobenzonitrile structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine motifs for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the difluoromethoxy group imparts improved activity and selectivity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronic Materials: Intermediate in the production of fluorinated organic semiconductors and electron-transport materials.
• Cross-Coupling Reactions: The nitrile and halogen substituents make it a suitable substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the effects of fluorine substitution.

Basic Information

Item	Details
Product Name	2-(Difluoromethoxy)-5-Fluorobenzonitrile
CAS No.	1017778-48-1
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	5-Fluoro-2-(difluoromethoxy)benzonitrile; 2-(Difluoromethoxy)-5-fluorobenzonitrile; 5-Fluoro-2-(difluoromethoxy)benzonitrile; Benzonitrile, 5-fluoro-2-(difluoromethoxy)-; 1017778-48-1; 2-Difluoromethoxy-5-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-5-Fluorobenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to confirm identity and quantify impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support cGMP production for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.