Description

3-Ethoxy-2,4-Difluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block, identified by CAS NO 1017778-32-3. This compound is valued for its unique molecular scaffold, which combines an electron-withdrawing nitrile group with fluorine and ethoxy substituents, enabling precise structural modifications in advanced synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery, particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the difluoroethoxy motif for enhanced bioactivity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, where its structure aids in tuning electronic properties and stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the difluorobenzonitrile core into more complex architectures.
• Chemical Research & Development: Utilized in academic and industrial labs for methodological studies and the development of new fluorination and functionalization techniques.

Basic Information

Product Name	3-Ethoxy-2,4-Difluorobenzonitrile
CAS No.	1017778-32-3
Molecular Formula	C9H7F2NO
Molecular Weight	183.16 g/mol
Synonyms	2,4-Difluoro-3-ethoxybenzonitrile; 3-Ethoxy-2,4-difluorobenzonitrile; Benzonitrile, 3-ethoxy-2,4-difluoro-; 2,4-Difluoro-3-ethoxybenzonitrile; 1017778-32-3
EINECS	Contact for details

Quality Control

Every batch of 3-Ethoxy-2,4-Difluorobenzonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.