Description

3-Ethoxy-2,4-Difluorophenylacetonitrile is a high-purity fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring both ethoxy and difluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and stability.
• Advanced Polymer Chemistry: Employed to introduce fluorinated phenylacetonitrile moieties into specialty polymers for enhanced chemical resistance.
• Cross-Coupling Reactions: The nitrile and halogen groups make it a suitable substrate for Suzuki, Sonogashira, and other palladium-catalyzed coupling reactions.
• Chemical Research & Development: A valuable scaffold for medicinal chemistry and material science exploration in academic and industrial laboratories.

Basic Information

Product Name	3-Ethoxy-2,4-Difluorophenylacetonitrile
CAS No.	1017778-26-5
Molecular Formula	C₁₀H₉F₂NO
Molecular Weight	197.18 g/mol
Synonyms	2-(3-Ethoxy-2,4-difluorophenyl)acetonitrile; (3-Ethoxy-2,4-difluorophenyl)acetonitrile; 3-Ethoxy-2,4-difluorobenzeneacetonitrile; 1017778-26-5; Acetonitrile, (3-ethoxy-2,4-difluorophenyl)-; 2,4-Difluoro-3-ethoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 3-Ethoxy-2,4-Difluorophenylacetonitrile is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.