Description

5-Methyl-2-(trifluoromethyl)phenylacetonitrile, 97% is a high-purity, versatile nitrile building block characterized by its trifluoromethyl and methyl substituents on the aromatic ring. This compound is essential for introducing the phenylacetonitrile moiety into complex molecules, with the trifluoromethyl group offering enhanced lipophilicity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for use in synthesizing active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group can improve biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for specialty chemicals used in electronic displays and organic light-emitting diodes.
• Organic Synthesis & Catalysis Research: Employed in academic and industrial labs for methodology development, including cyanoalkylation and palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry Studies: A valuable compound for investigating the effects of fluorine substitution on chemical reactivity and physical properties.
• Fine Chemical Manufacturing: Used in the custom synthesis of complex, high-value molecules for various technological applications.

Basic Information

Product Name	5-Methyl-2-(trifluoromethyl)phenylacetonitrile, 97%
CAS No.	1017778-24-3
Molecular Formula	C10H8F3N
Molecular Weight	199.17 g/mol
Synonyms	2-(Trifluoromethyl)-5-methylbenzyl cyanide; [5-Methyl-2-(trifluoromethyl)phenyl]acetonitrile; α-Cyano-5-methyl-2-(trifluoromethyl)toluene; 2-(5-Methyl-2-(trifluoromethyl)phenyl)acetonitrile; 5-Methyl-α,α,α-trifluoro-o-tolylacetonitrile; (5-Methyl-2-(trifluoromethyl)phenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-(trifluoromethyl)phenylacetonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.