Description

6-Chloro-2-Fluoro-3-Methoxybenzonitrile, 97% is a high-purity, multi-functional aromatic nitrile derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique halogenated and methoxylated structure, which provides versatile reactivity for constructing complex molecular architectures. This compound is essential for R&D chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated benzene core.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and advanced polymers due to its stable aromatic nitrile functionality.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	6-Chloro-2-Fluoro-3-Methoxybenzonitrile, 97%
CAS No.	1017777-72-8
Molecular Formula	C8H5ClFNO
Molecular Weight	185.58 g/mol
Synonyms	2-Fluoro-6-chloro-3-methoxybenzonitrile; 3-Methoxy-2-fluoro-6-chlorobenzonitrile; Benzonitrile, 6-chloro-2-fluoro-3-methoxy-; 6-Chloro-2-fluoro-3-methoxybenzonitrile; 1017777-72-8; 2-Fluoro-6-chloro-3-methoxy-benzonitrile
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Fluoro-3-Methoxybenzonitrile, 97% is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the specified 97% minimum assay. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality parameters. We adhere to cGMP principles where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.