Description

3,6-Difluoro-2-Methoxybenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluoro-methoxy substitution pattern enables precise modulation of biological activity and physicochemical properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated components in electronic display and lighting technologies.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or optical properties.
• Cross-Coupling Reactions: The nitrile and halogen groups make it a versatile substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new fluorination methodologies and constructing complex heterocycles.

Basic Information

Product Name	3,6-Difluoro-2-Methoxybenzonitrile
CAS No.	1010413-52-1
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	2-Methoxy-3,6-difluorobenzonitrile; 3,6-Difluoro-2-methoxybenzonitrile; Benzonitrile, 3,6-difluoro-2-methoxy-; 2-Cyano-1,4-difluoro-3-methoxybenzene
EINECS	Contact for details

Quality Control

Our 3,6-Difluoro-2-Methoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.