Description

2,5-Difluoro-3-Methylbenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for selective functionalization and incorporation into complex molecular architectures. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for constructing bioactive molecules, particularly in the synthesis of fluorinated drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, contributing to improved thermal stability, dielectric anisotropy, and emission properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of reactive halogens (fluorine) and the cyano group.
• Fluorine Chemistry Library: A valuable building block for creating focused libraries of fluorinated compounds in medicinal and materials chemistry research.
• Advanced Polymer Synthesis: Can be utilized to introduce fluorinated aromatic units into polymer backbones, modifying properties like chemical resistance, thermal stability, and optical characteristics.

Basic Information

Product Name	2,5-Difluoro-3-Methylbenzonitrile
CAS No.	1003712-20-6
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	3-Methyl-2,5-difluorobenzonitrile; 2,5-Difluoro-3-methylbenzonitrile; Benzonitrile, 2,5-difluoro-3-methyl-; 2,5-Difluoro-m-tolunitrile; 1-Cyano-2,5-difluoro-3-methylbenzene
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-3-Methylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.