Description

4,5-Difluoro-2-Methylbenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. This compound is valued for its role in introducing both fluorine atoms and a versatile nitrile functional group into complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where its structural motifs can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging fluorine's properties to improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated structure.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4,5-Difluoro-2-Methylbenzonitrile
CAS No.	1003708-82-4
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	2-Methyl-4,5-difluorobenzonitrile; 4,5-Difluoro-o-tolunitrile; Benzonitrile, 4,5-difluoro-2-methyl-; 2-Cyano-4,5-difluorotoluene
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Methylbenzonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.