Description

3,5-Difluoro-2-Methylbenzonitrile is a high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluoro-methyl substitution pattern enables precise modulation of biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine atoms into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where fluorine atoms enhance metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving performance and stability.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex, fluorinated aromatic systems.
• Chemical Research & Development: A valuable scaffold for medicinal chemistry and material science research exploring structure-activity relationships (SAR).
• Fluorine Chemistry Studies: Used as a model compound in academic and industrial research focused on fluorination techniques and the properties of fluorinated arenes.

Basic Information

Item	Details
Product Name	3,5-Difluoro-2-Methylbenzonitrile
CAS No.	1003708-74-4
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	2-Methyl-3,5-difluorobenzonitrile; 3,5-Difluoro-o-tolunitrile; 2-Cyano-1,3-difluoro-6-methylbenzene; 2-Methyl-3,5-difluorophenyl cyanide; Benzonitrile, 3,5-difluoro-2-methyl-; 3,5-Difluoro-2-methylbenzenecarbonitrile; (3,5-Difluoro-2-methylphenyl)methanenitrile
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Methylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.