Description

5-Bromo-3-Chloro-2-Fluorobenzonitrile is a high-purity, multi-halogenated benzonitrile derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the halogen atoms contribute to bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating molecular probes, enzyme inhibitors, and labeled compounds for diagnostic applications.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination, enabling rapid diversification of chemical libraries.

Basic Information

Product Name	5-Bromo-3-Chloro-2-Fluorobenzonitrile
CAS No.	1000577-76-3
Molecular Formula	C7H2BrClFN
Molecular Weight	234.45 g/mol
Synonyms	2-Fluoro-5-bromo-3-chlorobenzonitrile; 3-Chloro-5-bromo-2-fluorobenzonitrile; Benzonitrile, 5-bromo-3-chloro-2-fluoro-; 5-Bromo-3-chloro-2-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Chloro-2-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.