Description

2-Amino-3-Bromo-5-Chloro-6-Fluorobenzonitrile is a high-purity, multi-halogenated benzonitrile derivative serving as a critical advanced intermediate in modern synthetic chemistry. Its unique substitution pattern makes it a valuable scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated aromatic motifs into their target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in areas targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the halogenated aromatic core provides specific biological activity and stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution, enabling the rapid exploration of chemical space.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex, high-performance colorants and fluorescent markers.

Basic Information

Item	Detail
Product Name	2-Amino-3-Bromo-5-Chloro-6-Fluorobenzonitrile
CAS No.	1000577-72-9
Molecular Formula	C7H3BrClFN2
Molecular Weight	249.47 g/mol
Synonyms	2-Amino-3-bromo-5-chloro-6-fluorobenzonitrile; 3-Bromo-5-chloro-6-fluoro-2-aminobenzonitrile; 2-Amino-3-bromo-5-chloro-6-fluorophenyl cyanide; Benzonitrile, 2-amino-3-bromo-5-chloro-6-fluoro-; 6-Fluoro-2-amino-3-bromo-5-chlorobenzonitrile; 5-Chloro-6-fluoro-2-amino-3-bromobenzonitrile; CAS 1000577-72-9
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Bromo-5-Chloro-6-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) are provided with every shipment, detailing all specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.