Description

3-Chloro-2-Fluoro-6-Iodobenzonitrile is a high-purity halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogen functionalities into their target structures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its electron-withdrawing and steric properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	3-Chloro-2-Fluoro-6-Iodobenzonitrile
CAS No.	1000577-68-3
Molecular Formula	C7H2ClFIN
Molecular Weight	281.45 g/mol
Synonyms	2-Fluoro-3-chloro-6-iodobenzonitrile; 6-Iodo-3-chloro-2-fluorobenzonitrile; 3-Chloro-2-fluoro-6-iodo-benzonitrile; Benzonitrile, 3-chloro-2-fluoro-6-iodo-; 1000577-68-3; 3-Chloro-2-fluoro-6-iodobenzonitrile; 2-Fluoro-3-chloro-6-iodobenzonitrile
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-6-Iodobenzonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality management system is designed to meet the rigorous standards required by the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.