Description

2-Amino-5-Bromo-3-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic nitrile building block. This compound matters for its unique trifluoromethyl and bromo substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	2-Amino-5-Bromo-3-(Trifluoromethyl)Benzonitrile
CAS No.	1000571-53-8
Molecular Formula	C8H4BrF3N2
Molecular Weight	265.03 g/mol
Synonyms	5-Bromo-2-amino-3-(trifluoromethyl)benzonitrile; 2-Amino-5-bromo-α,α,α-trifluoro-m-toluonitrile; 3-Cyano-4-bromo-6-(trifluoromethyl)aniline; Benzonitrile, 2-amino-5-bromo-3-(trifluoromethyl)-; 4-Bromo-2-cyano-6-(trifluoromethyl)aniline; 2-Amino-5-bromo-3-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Bromo-3-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.