Description

4-Methoxy-3-(trifluoromethyl)phenylacetonitrile, 97% is a high-purity, multi-functional chemical intermediate featuring a trifluoromethyl group and a nitrile moiety. This compound is valued for its role in introducing the metabolically stable trifluoromethyl group and the versatile nitrile functionality into target molecules, enabling the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-deficient aromatic units in electronic materials for displays and lighting.
• Functional Polymer Monomers: Incorporated into polymers to impart specific chemical resistance, thermal stability, or optical properties.
• Cross-Coupling Reactions: The aryl bromide/chloride derivative (if synthesized from this nitrile) is a valuable substrate for Suzuki, Heck, and other palladium-catalyzed couplings.
• Nitrile Transformation Chemistry: The nitrile group can be hydrolyzed to carboxylic acids, reduced to amines, or converted into tetrazoles and other heterocycles.

Basic Information

Product Name	4-Methoxy-3-(Trifluoromethyl)Phenylacetonitrile, 97%
CAS No.	1000555-32-7
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	2-(4-Methoxy-3-(trifluoromethyl)phenyl)acetonitrile; [4-Methoxy-3-(trifluoromethyl)phenyl]acetonitrile; 3-Trifluoromethyl-4-methoxyphenylacetonitrile; 4-Methoxy-α,α,α-trifluoro-m-toluonitrile; (4-Methoxy-3-trifluoromethylphenyl)acetonitrile; 2-(4-Methoxy-3-trifluoromethylphenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 4-Methoxy-3-(trifluoromethyl)phenylacetonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.